Leishmaniases are neglected diseases that are endemic in many tropical and sub-tropical\nCountries. Therapy is based on different classes of drugs which are burdened by severe side\neffects, occurrence of resistance and high costs, thereby creating the need for more efficacious,\nsafer and inexpensive drugs. Herein, sixteen 9-thioxanthenone derivatives (lucanthone analogues)\nand four compounds embodying the diarylethene substructure of amitriptyline (amitriptyline\nanalogues) were tested in vitro for activity against Leishmania tropica and L. infantum promastigotes.\nAll compounds were characterized by the presence of a bulky quinolizidinylalkyl moiety.\nAll compounds displayed activity against both species.......................
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